8. Suspension properties and characterization of aluminum adjuvanted vaccines AuthorAlex Langford, Michael Bruchsaler and Manish Gupta Year2022 Sourcein Practical Aspects of Vaccine Development, LanguageEnglish Pages243 2524LUMiSizerLSpharmaceutical 3 more vaccinecentrifugal sedimentationPfizer Inc. More details EditionEds. Parag Kolhe, Satoshi Ohtake LocationElsevier Inc., found online 6.10.2021, 12:24 Internal reference2524 Open publication →
8. Suspension properties and characterization of aluminum adjuvanted vaccines AuthorAlex Langford, Michael Bruchsaler and Manish Gupta Year2022 SourceIndividual chapter LanguageEnglish Pages225-266 2609LUMiSpocLSpocsingle particle sizing techniques 11 more pharmaceuticalvaccinePfizer Inc.LUMiSizerLSanalytical centrifugationparticle size distributionanalysissingle particle countingspls technologysingle particle light scattering More details EditionPractical Aspects of Vaccine Development Internal reference2609 Open publication →
A combined approach for modifying pea protein isolate to greatly improve its solubility and emulsifying stability AuthorZijian Zhi, Lei Yan, Hao Li, Koen Dewettinck, Paul Van der Meeren, Rui Liu, Filip Van Bockstaele Year2022 SourceFood Chemistry LanguageEnglish Pages131832 LUMiSizerLS2680Pea protein isolate 14 more PH-shiftingUltrasoundHeatingSolubilityEmulsion stabilityFood Structure and Function (FSF)Department of Food TechnologySafety and HealthFaculty of Bioscience EngineeringGhent UniversityState Key Laboratory of Food Nutrition and SafetyTianjin University of Science & TechnologyParticle and Interfacial Technology Group (PaInT)Department of Green Chemistry and 11 Technology More details Edition380 Internal reference2680 Open publication →
A rapid testing method for fatigue in metal additive manufacturing AuthorInga Meyenborg Year2022 SourceInternational Conference Dispersion Analysis & Materials Testing 2022 LanguageEnglish Pages1-2 2544Additive ManufacturingMetal FatigueCentrifuge 7 more Novel test methodAlSi7Mg0.6LFracLUMiFracit was investigated whether the LUMiFrac centrifugewhich is usually used to determine the strength of adhesive bondscan be utilized for testing tensile and fatigue properties of AlSi7Mg0.6 specimens manufactured with the additive manufacturing (AM) technology Laser Beam Melting (LBM). Fraunhofer IFAM Bremen More details EditionNominated for LUM Young Scientist Award 2022- Abstracts LocationVirtual, 24-25 January 2022 Internal reference2544 Open publication →
A Resolved Simulation Approach to Investigate the Separation Behavior in Solid Bowl Centrifuges Using Material Functions AuthorHelene Katharina Baust, Simon Hammerich, Hartmut König, Hermann Nirschl and Marco Gleiß Year2022 SourceSeparations LanguageEnglish Pages248 2875KITBASF SELUMiSizer 14 more LSThe separation of finely dispersed particles from liquids is a basic operation in mechanical process engineering. On an industrial scalecontinuously operating decanter centrifuges are often usedwhose separation principle is based on the density difference between the solid and the liquid phase due to high g-forces acting on both phases. The design of centrifuges is based on the experience on the individual manufacturer or simplified black box modelswhich only consider a stationary state. Neither the physical behavior of the separation process nor the sediment formation and its transport is considered. In this worka computationally-efficient approach is proposed to simulate the separation process in decanter centrifuges. Therebythe open-source computation software OpenFOAM was used to simulate the multiphase flow within the centrifuge. Sedimentationconsolidation of the sedimentand its transport are described by material functions which are derived from experiments.The hindrance function (Equation (5)) allows predicting the influence of the solids volume fraction on the sedimentation behavior and was determined by varying the solids volume fraction of the slurry using an analytical centrifuge (LUMiSizerLUM GmbHBerlinGermany). To measure the settling velocitysamples of the dilution series are filled into cuvettessolid-liquid separation; decanter centrifuges; CFD simulation More details Edition9 Internal reference2875 Open publication →
Amphiphilic Thermoresponsive Poly(Hydroxyaminoethers) as Effective Emulsifiers for Preparation of Waterborne Epoxy Resins AuthorYing-Chi Huang, Li-Ting Wang, Shu-Wei Hsu, Tai-Fu Lin, Ying-Chih Liao, Wen-Ying Chiu, Hsin-Wei Lin, Chien-Hsin Wu,Ru-Jong Jeng, and Shih-Huang Tung Year2022 SourceMacromol. Mater. Eng. LanguageEnglish Pages2100668 2705LUMiSIzerLS; Amphiphilic poly(hydroxyaminoethers) (PHAEs) with thermoresponsive solubility in aqueous solutions are developedThe sedimentation behaviors of the emulsions were analyzed using a dispersion analyzer 5 more he sedimentation velocity under normal gravity was estimated by extrapolation of the measured sedimentation velocity at high relative centrifugation forcescorrosion resistancepoly(hydroxyaminoethers)reversible solubilitywaterborne epoxy resins More details Edition307 Internal reference2705 Open publication →
Análisis comparativo del posible efecto booster FPS y actividad antioxidante de un concentrado de café y dos antioxidantes sintéticos, en una fórmula de protección solar modalidad Investigación AuthorGarnica Alvarez, Luisa Fernanda Year2022 SourceTrabajo de grado - Pregrado LanguageSpanish 2669LUMiSizerLSOne of the waste products of the coffee manufacturing process is the mucilage 30 more whichlike the seedcontains antioxidant properties and other usable compounds such as carbohydratesfiber and reducing sugars; thusin order to explore different alternatives using coffee mucilage as a significant source of antioxidantsits inclusion in sun protection formulas was evaluated in order to obtain products with dual action (antioxidant and protection against solar radiation) and thus prevent the harmful effects caused by ultraviolet radiationsuch as photoaging and skin cancer. Thereforethe objective of this study is to establish whether the coffee mucilage extract contains a greater boosting effect of the sun protection factor and antioxidant action compared to two synthetic antioxidants for its possible application in sun protection formulas. The antioxidant action was evaluated through the DPPH (11-diphenyl-2-picrylhydrazyl) free radical production determination test and through the intracellular free radical detection test by fluorescencewhere the FPS was determined in parallel. in vitroevaluating the stability of the formula after the inclusion of antioxidants by determining the physicochemical properties and characterizing the formulas by means of ...and Lumisizer equipment. Uno de los productos de residuo del proceso de fabricación del café es el mucílagoque al igual que la semillacontiene propiedades antioxidantes y otros compuestos aprovechables como carbohidratosfibra y azúcares reductores; es así que con el fin de explorar diferentes alternativas utilizando el mucílago del café como fuente significativa de antioxidantesse evaluó su inclusión en fórmulas de protección solar con la finalidad de obtener productos con acción dual (antioxidante y protección ante la radiación solar) y así prevenir los efectos nocivos que causa la radiación ultravioletacomo lo son el foto-envejecimiento y cáncer de piel. Por lo tantoel objetivo del presente estudio es establecer si el extracto de mucilago de café contiene mayor efecto potencializador (booster) del factor de protección solar y acción antioxidante en comparación a dos antioxidantes sintéticos para su posible aplicación en fórmulas de protección solar. La acción antioxidante se evaluó a través de la prueba de determinación de producción de radicales libres DPPH (11-difenil-2- picrilhidracilo) y por medio de la prueba de detección de radicales libres intracelulares por fluorescenciadonde paralelamente se determinó el FPS de manera in vitroevaluando la estabilidad de la fórmula tras la inclusión de los antioxidantes por medio de la determinación de las propiedades fisicoquímicas y caracterizando las fórmulas por medio de los equipos ...y Lumisizer. FoodnutritionbeveragesCaféProtectores SolaresRayos UltravioletaAntioxidantesIndustria Cosméticacosmeticshome and personal carehpc More details Editionwith English abstract LocationUniversidad de Ciencias Aplicadas y Ambientales, Bogotá, Colombia Internal reference2669 Open publication →
Analytical characterization of non-alcoholic beverages AuthorFanni Scholz Year2022 SourceWebinar LanguageEnglish Pages1-37 2625LUMiSizerLSLRPSA 9 more LUMiReader PSASoft drinksBeveragesSpirulinaOrange drinkPineapple juiceVelocity distributioninstability indexOstwald-Ripening More details EditionWebinar Internal reference2625 Open publication →
Analytical characterization of starch Part 1: Investigation of suspensions and pastes AuthorFanni Scholz Year2022 SourceWebinar LanguageEnglish Pages1-34 2622LUMiReader PSALRPSALUMiFrac 23 more LFracLUMiSizerLSCase studies for starch suspensionsCase study for starch pastesSTEP Technology® for particle and dispersion characterizationCAT Technology® for adhesion determinationCase study for dried starch pasteStabilizerThickenerSweetener syrupTextile sizing and adhesiveWet adhesive in the paper industryBinding agent for tablets and capsulesCharacterisation and comparison of starch suspensions (maizepotato and wheat)Characterization and comparison of different starches and flours by measuring the sedimentationpacking and compression behaviour in the centrifugal fieldVelocity distributionssedimentation velocitypotato starchcake flourStarch pastes More details EditionWebinar Internal reference2622 Open publication →
Analytical characterization of starch Part 2: Starch as emulsion stabilizer AuthorFanni Scholz Year2022 SourceWebinar LanguageEnglish Pages1-25 2623LUMiSizerLSLUMiFuge 9 more LFComparison of the properties of coconut milk stabilized with starch and maize grainsComparison of the stability of coconut milk emulsions with and without maize starchdifferent maize starchesHydrophobically modified starchesComparison of the emulsifying properties of amphiphilic polymersCFG: Corn fiber gumOSAs s: Octenyl succinate anhydride modified starch GA: Gumarabic SSPS: Soluble soybean polysaccharidesof modified pea and maize starch More details EditionWebinar Internal reference2623 Open publication →
Analytische Charakterisierung von alkoholfreien Getränken AuthorFanni Scholz Year2022 SourceWebinar LanguageGerman Pages1-37 2624STEP Technology® für Partikel und DispersionscharakterisierungAromaemulsionen und FarbstoffeErfrischungsgetränke 16 more FruchtsäfteSpirulinaLUMiSizerLSLRPSALUMiReader PSAVergleich der Stabilität von 3 OrangenlimonadenInstabilitätsindexSedimentationsgeschwindigkeitsverteilungMehrere trübe Getränkeemulsionen wurden mit Orangenterpenen oder mittelkettigen Triglyceriden als ÖlphaseEmulgatoren (Gummi Arabicum oder chemisch modifizierte Stärke)in Gegenwart oder Abwesenheit eines Beschwerungsmittels ( Estergummi )AufrahmungOstwald ReifungGalgantölAnanassaft More details EditionWebinar Internal reference2624 Open publication →
Anomalous transport of colloids in heterogeneous porous media: A multi-scale statistical theory AuthorDian Fan, Emily Chapman, Aisha Khan, Francesco Iacoviello, Gediminas Mikutis, Ronny Pini, Alberto Striolo Year2022 SourceJournal of Colloid and Interface Science LanguageEnglish Pages94-105 2722The particles were ∼ 150 nm in diameter (scanning transmission electron microscopy (STEM) and LUMiSizer)LSColloid Porous media Multi-scale approach Anomalous transport Digital rock 2 more Transport of suspended colloids in heterogeneous porous media is a multi-scale process that exhibits anomalous behavior and cannot be described by the Fickian dispersion theory. Although many studies have documented colloids’ transport at different length scalesa theoretical basis that links pore- to core-scale observations remains lacking. It is hypothesized that a recently proposed pore-scale statistical kinetic theory is able to capture the results observed experimentally. More details Edition617 Internal reference2722 Open publication →
Antifungal Activity and Stability of Fluconazole Emulsion Containing Ionic Liquids Explained by Intermolecular Interactions AuthorBruno L. Hennemann, Caroline R. Bender , Guilherme S. Moleta, Ânderson R. Carvalho, Luana C. G. Bazana, Alexandre M. Fuentefria and Clarissa P. Frizzo Year2022 SourcePharmaceutics LanguageEnglish Pages710 LUMiSizerLS2687ionic liquid 12 more ultrasoundemulsionfluconazoleintermolecular interactionantifungal activityDetermination of Emulsion StabilityEmulsion Stability Tests The physical stability of the IL emulsions containing fluconazoleprepared using mechanical stirring (MS) and ultrasound (US)accelerated stability experimentsthe evaluation of intermolecular interactionsand antifungal assays for fluconazole emulsions prepared using ultrasound (US) and magnetic stirring (MS) in the presence of ionic liquids derived from 1n-(3-methylimidazolium-1-yl)alkane bromide More details Edition14 Internal reference2687 Open publication →
API-polymer interactions in Sepineo P600 based topical gel formulation- impact on rheology AuthorAbu Zayed Md Badruddoza, Thean Yeoh, Jaymin C. Shah Year2022 SourceInternational Journal of Pharmaceutics LanguageEnglish Pages121824 2673transferred using a specific needle into the Lumisizer transparent cell with a 2 mm path All Lumisizer measurements were conducted with at least three replicatesLSSemisolid formulation 9 more Sepineo P600 RheologyGelEmulgeltopical gel and emulsion gel were formulated using Acrylamide/ Sodium Acryloyldimethyl taurate copolymer (Sepineo P600) as a gelling agentand their rheological attributes and physical stability were evaluated upon incorporation of API. Lidocainea free base drug (pKa 7.92) was used as a model drug in all formulations. Medium- chain Triglycerides (MCT) was used as a dispersed phase to prepare the emulgel. Drug Product DesignWorldwide ResearchDevelopment and MedicalPfizer Inc. More details Edition621 Internal reference2673 Open publication →
APPROACHES TO ENHANCE THE FUNCTIONAL PROPERTIES OF PEA PROTEIN THROUGH PROCESSING AuthorTravis G. Burger Year2022 SourceDISSERTATION LanguageEnglish Pages1-24 2632LUMiFugeLFLUMiSizer 3 more LSPea protein is a trending food ingredientlumifuge stability profiles of oil-in-water emulsions stabilized by commercial pea proteins More details EditionPreview LocationFaculty of The Graduate College at the University of Nebraska, USA Internal reference2632 Open publication →
Bericht über die 10. Internationale Konferenz für Dispersionsanalyse und Materialprüfung Berlin, virtuell, 2022 AuthorF. Scholz, M. Hood Year2022 SourceDispersion Letters LanguageGerman Pages1-4 2769Hansen Dispergierbarkeits- und LöslichkeitsparameterKRONOS INTERNATIONAL Inc. berichtete von der Untersuchung der Anwendbarkeit der Hansen-Löslichkeitsparameter für die Entwicklung von Titandioxid-PigmentenTitandioxid-Photokatalysatoren 19 more Schott AG hat in seinen Vortrag einen Ansatz zur Ermittlung der optimalen Zusammensetzung von Mehrkomponenten-Lösungsmittelmischungen für die Dispersion von Mehrkomponenten-PartikelkollektivenHansen-Löslichkeitsparameter zur systematischen Untersuchung der Stabilität von Kohlenstoffdispersionen in unterschiedlichen organischen LösungsmittelnEffekt von Xanthan auf die Stabilität von Wasser-in-Wasser-Emulsionen auf Basis von POE (Polyethylenoxid) und DextranScale-up von Vollmantelzentrifugen oder DekanternKRONOS INTERNATIONAL Inc. ist es gelungenSedimente im Detail im LUMiReader®X-Ray zu untersuchenum die effektive Agglomerat-Dichte von TitandioxidAblagerung von Asphalten in einem Gemisch aus Rohöl und n-Heptan unter Einsatz von InhibitorenMuschelinspirierte Catechol-haltige Polymere sind eine vielversprechende Grundlage für die Entwicklung starker biogener Klebstoffe.Additive Fertigungstechnologien ermöglichen die Verwirklichung der Ziele von LeichtbaukonstruktionenSeparationsstabilität von verschiedenen Mischungen von Agrochemikalien untersucht und eine Verbesserung der Stabilität durch die Zugabe von HilfsstoffenLUMiSizerLSLUMiFracLFracLUMiReader PSALRPSALUMiReader X-RayLRX More details EditionSeminars & Events Location10. Konferenz für Dispersionsanalyse und Materialtestung, 24. -25. Januar 2022, virtuell Internal reference2769 Open publication →
BIOAKTIVNÍ LÁTKY PRO PLEŤOVÉ KRÉMY: STANOVENÍ STABILITY PLEŤOVÉHO KRÉMU S OBSAHEM KOZÍHO MLÉKA BIOACTIVE SUBSTANCES FOR FACE CREAM: DETERMINATION OF STABILITY OF FACE CREAM INCORPORATED WITH GOAT'S MILK AuthorTereza Dostálová Year2022 SourceBAKALÁŘSKÁ PRÁCE, BACHELOR'S THESIS LanguageCzech Pages1-78 2800LUMiSizerLSdairy 16 more Pleťový krémstabilitakozí mlékoreologieDSCFTIRoptická mikroskopieSkin creamstabilitygoat milkrheologyoptical microscopycosmeticshpcstability trial of a skin cream incorporated with goat milk lyophilizatesMěření prvotní stability krému More details LocationVYSOKÉ UČENÍ TECHNICKÉ V BRNĚ, BRNO UNIVERSITY OF TECHNOLOGY, FAKULTA CHEMICKÁ, FACULTY OF CHEMISTRY, ÚSTAV FYZIKÁLNÍ A SPOTŘEBNÍ, CHEMIE INSTITUTE OF PHYSICAL AND APPLIED CHEMISTRY Internal reference2800 Open publication →
Candelilla wax-based oleogels versus palm oil: evaluation of physical properties of innovative and conventional lipids using optical techniques AuthorIwona Szymańska, Anna Żbikowska, Sylwia Onacik-Gür Year2022 SourceJournal of the Science of Food and Agriculture LanguageEnglish Pages2309-2320 LSLUMiSIzer2714palm oil in food production affects high consumption of long-chain saturated fatty acids 3 more which increases the risk of cardiovascular disease. Solid or semi-solid wax-based oleogels obtained as a result of edible oils structuring can be an alternative. centrifugal stability analysisedible lipid quality control at various stages of processing or storageLUMiSizer can be a modern alternative to a conventional centrifuge in oleogels stability testing More details Edition102, Issue 6 Internal reference2714 Open publication →
Carboxymethyl-Dextran-Coated Superparamagnetic Iron Oxide Nanoparticles for Drug Delivery: Influence of the Coating Thickness on the Particle Properties AuthorChiara Turrina, Davide Milani, Anna Klassen, Diana M. Rojas-González, Jennifer Cookman, Matthias Opel, Barbara Sartori, Petra Mela , Sonja Berensmeier and Sebastian P. Schwaminger Year2022 SourceInt. J. Mol. Sci. LanguageEnglish Pages14743 2992carboxymethyl dextran; iron oxide nanoparticles; antimicrobial peptide; magnetically controlled drug delivery; agglomeration behaviorLRPSALUMiReader PSA; Nanomedicine has introduced novel therapeutic and diagnostic capabilities that can address previously inaccessible issues in medicine 3 more e.g.targeted delivery or improved medical imaginghe sedimentation rate as a function of the magnetic field was assessed with the LUMiReader More details Edition23 Internal reference2992 Open publication →
Challenges in the Development of Drug Device Combination Products for Biopharmaceuticals AuthorFabian Alexander Moll Year2022 SourceDissertation zur Erlangung des Doktorgrades LanguageEnglish Pages1-183 2848Creaming VelocityLUMiSizerLS 15 more Particle Size Distribution via Analytical CentrifugationPSDPSAcumulative volume weighted particle size distributionRelevance of Combination Products for Injectables With the growth of the biopharmaceutical market in the last decades the development of ready-to use drug device combination products (DDCP) for parenterals became increasingly important. Especially the market for monoclonal antibodies (mAbs) grew significantly making them the major class of biopharmaceuticals and a mainstream molecular entityNext to mAbsvarious novel protein designs like bispecific antibodiesantibody-drug conjugates or fusion proteins are developed [7]. Additionallythe successful development of mRNA-based vaccines against the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) can be expected to give a boost to the development of further RNA therapeutics . All those compounds rely on injection. DDCPs are a preferred packaging system as they ease the handling and administration of parenteral drugs . Compared to vialsthey allow injection without further handling steps making the administration easiersaferand faster. The risk of contamination is significantly reducedmany devices already include safety systems preventing from needle stick injuriesand since the syringes do not need manual withdrawal dosing accuracy is in general higher. The advantages are not only relevant for health care professionals. They eventually enable patient for self-administrationwhich provides cost savings for the health care sector and increases compliance which is particularly important in treatment of chronic diseases More details LocationFakultät für Chemie und Pharmazie der Ludwig-Maximilians-Universität München, Germany Internal reference2848 Open publication →
